Rheumatoid joint inflammation (RA) is a problem that can influence several components of your body. It creates discomfort and also restrictions your activity, and also it becomes worse the longer it goes neglected.

There are several therapies for RA that can aid you handle your signs and symptoms and also boost your high quality of life.

Have a look at 2 such medications: methylprednisolone and also prednisone. Understanding exactly how they’re comparable and also exactly how they’re not can aid you have a much more educated discussion with your physician concerning the appropriate RA therapy for you.

vs. prednisone

Methylprednisolone and also prednisone both come from a course of medications called corticosteroids. They minimize swelling. For individuals with RA, these medications aid by decreasing immune actions that can result in swelling, discomfort, and also joint damages.

Methylprednisolone and also prednisone are extremely comparable medications. There is a distinction in their family member toughness: 8 milligrams (mg) of methylprednisolone amounts 10 mg of prednisone.

The adhering to table contrasts several of the functions of these 2 medicines.


What course is it?

What are the brand-name variations?
Medrol, Depo-Medrol, Solu-Medrol.

Is a common variation readily available?
of course.
of course.

What kinds does it be available in?
dental tablet computer, injectable service *.
dental tablet computer, dental service.

What is the common size of therapy?
short-term for flare-ups, long-term for upkeep.
short-term for flare-ups, long-term for upkeep.

Exists a threat of withdrawal with this medicine?
of course †.
of course †.

* Just doctor provide this type.

† If you have actually been taking this medicine for longer than a couple of weeks, do not quit taking it without speaking with your physician. You’ll require to reduce the medicine gradually to stay clear of withdrawal signs and symptoms such as anxiousness, nausea or vomiting, difficulty, and also sweating resting.

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Prednisone is available in these toughness:

  • common prednisone service: 5 mg/mL
  • Prednisone Intensol (service concentrate): 5 mg/mL
  • Rayos (extensive launch tablet computer): 1 mg, 2 mg, 5 mg
  • common prednisone tablet computer: 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, 50 mg
  • common prednisone pack: 5 mg, 10 mg

Methylprednisolone comes as a dental tablet computer in comparable toughness to prednisone:

  • Medrol: 2 mg, 4 mg, 8 mg, 16 mg, 32 mg
  • Medrol Pak: 4 mg
  • common methylprednisolone: 4 mg, 8 mg, 16 mg, 32 mg
  • common methylprednisolone pack: 4 mg

In addition, methylprednisolone comes as an injectable service that a doctor have to infuse. That is, you will not provide on your own the medicine in your home. The injectable service is available in these toughness:

  • Depo-Medrol: 20 mg/mL, 40 mg/mL, 80 mg/mL
  • Solu-Medrol: 40 mg, 125 mg, 500 mg, 1,000 mg, 2,000 mg
  • common methylprednisolone acetate: 40 mg/mL, 80 mg/mL
  • common methylprednisolone salt succinate: 40 mg, 125 mg, 1,000 mg

Price and also accessibility

Both of these medications are readily available at a lot of drug stores. They set you back concerning the very same, however prednisone is somewhat less costly than methylprednisolone. GoodRx can aid you discover one of the most existing prices.

If expense is an issue for you, both methylprednisolone and also prednisone can be found in common variations, besides the extended-release prednisone tablet computer. Prednisone extended-release tablet computer is just readily available as the brand-name medicine Rayos.

Brand-name medications are a lot more pricey than common variations. You and also your physician will certainly choose which type is best for you, so talk with them concerning any type of issues you have concerning spending for your drug.

That claimed, methylprednisolone and also prednisone are additionally both covered by a lot of medical insurance strategies. The brand-name medications might call for previous consent from your physician.


Methylprednisolone and also prednisone have the very same negative effects and also the very same lasting threats. The threats that are related to these 2 medicines are because of the course of medicines that they come from– corticosteroids.

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and also prednisone.


Both methylprednisolone and also prednisone can engage with various other medications. When a compound alters the means a medication jobs, a communication is. It can be dangerous or avoid either medicine from functioning well.

Inform your physician concerning all vitamins, medicines, or natural herbs you’re taking. This can aid your physician avoid feasible communications.

Both methylprednisolone and also prednisone engage with the adhering to medications:

  • pain killers (Bufferin)
  • ketoconazole
  • phenobarbital
  • phenytoin
  • rifampin (Rifadin)
  • warfarin (Coumadin)
  • metyrapone (Metopirone)

Methylprednisolone additionally connects with an extra medicine called cyclosporine (Sandimmune, Neoral, Gengraf), which is made use of to subdue the body immune system.

with various other clinical problems

Make certain you provide your physician your full case history. Particularly, inform your physician if you have any one of the list below problems:

  • any type of head injuries
  • cirrhosis
  • diabetes mellitus
  • psychological issues
  • herpes simplex of the eye
  • hypertension
  • hypothyroidism
  • kidney issues
  • mental disease
  • myasthenia gravis
  • weakening of bones
  • seizures
  • consumption
  • ulcerative colitis
  • abscess

Any one of these problems might make complex treatment with methylprednisolone or prednisone.

with your physician

Methylprednisolone and also prednisone are extremely comparable medications. Due to the fact that of the seriousness of your condition, one might function far better for you than the various other merely. One medicine might be readily available in a much more hassle-free type.

Speak to your physician concerning these 2 medications in addition to various other RA therapy choices to obtain a concept of the options that will certainly function best for you.

To find out about various other choices for RA, look into this listing of rheumatoid joint inflammation medicines.

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